江西科学

目的：探究补肾清热合剂治疗儿童外周性性早熟的临床疗效及安全性。方法：选取江西省儿童医院收治的40例外周性性早熟患儿，给予补肾清热合剂治疗，观察患儿身高、体重、子宫容积、卵巢容积、雌激素水平变化、乳房分期及有无不良事件发生。结果：补肾清热合剂治疗3、6个月时身高逐步增长，但9个月时部分患儿未增长，12个月时继续增长；治疗3、6个月时，体重缓慢增加；治疗3、6、9、12个月时，患儿子宫容积和卵巢容积缓慢增大；治疗3个月时患儿雌二醇水平迅速下降，但治疗6、9、12个月时，部分患儿雌激素水平再次升高；补肾清热合剂治疗后，患儿乳房分期保持B2-B3不变。全部患儿口服补肾清热合剂期间无不良反应发生。结论：补肾清热合剂治疗外周性性早熟患儿疗效确切，且不良反应较小，值得应用。

Objective: To explore the clinical efficacy and safety of Bushen Qingre mixture in the treatment of children with peripheral precocious puberty. Methods: A total of 40 children with peripheral precocious puberty in our hospital were selected and treated with Bushen Qingre mixture. The height, weight, uterine volume, ovarian volume, estrogen levels, breast stage and adverse events were observed. Results: The height of children gradually increased after 3 and 6 months of treatment with Bushen Qingre mixture, but some children did not increase at 9 months, and continued to increase at 12 months. After 3 to 6 months of treatment, the weight increased slowly. After 3 to 12 months of treatment, uterine volume and ovarian volume increased slowly. The level of estradiol decreased rapidly after 3 months of treatment, but increased again after 6 to 12 months of treatment in some children. After treatment with Bushen Qingre mixture, the breast stage of the child remained unchanged at B2-B3. All children had no adverse reactions during oral administration of Bushen Qingre mixture. Conclusion: Bushen Qingre mixture is effective in the treatment of children with peripheral precocious puberty, and has less adverse reactions. It is worthy of application.